Annotation systems. cGMP-dependent protein kinase 2 Add BLAST: 761: Amino acid modifications. Protein knowledgebase. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.

Sequence archive. Sequence clusters. Protein sets from fully sequenced genomes. The role of cGMP as a second messenger in physiological and pathophysiological processes is widely appreciated 1 – 3.The successes of drugs that target the cGMP-signaling pathway [nitrovasodilators and PDE5 inhibitors (Viagra, Cialis, and Levitra)] have inspired interest in other cardiovascular benefits that might derive from a better understanding of this pathway 2, 4 – 7. H-9 competes with ATP and is thus less effective in cells that have … Cyclic GMP (cGMP) is an important regulator in eukaryotes, and cGMP-dependent protein kinase (PKG) plays a key role in perceiving cellular cGMP in diverse physiological processes in animals. Feature key Position(s) Description Actions Graphical view Length Lipidation i: 2: N-myristoyl glycine 1 Publication, , , , 1: Modified residue i: 110: Phosphoserine By similarity. 1. cGMP-Dependent Protein Kinase I Phosphorylation Sites in Intact Proteins. Protein kinase A, more precisely known as adenosine 3',5'-monophosphate (cyclic …

Help. UniRef. However, the molecular identity, property, and function of PKG in plants remain elusive.

History.

Proteomes. 1: Modified residue i: 117: Phosphoserine By similarity.

cGMP-dependent protein kinases (PKG) exhibit diverse physiological functions in the mammalian system e.g., in vascular and gastrointestinal smooth muscles, in platelets, in kidney, in bone growth, nociception and in the central nervous system.Furthermore, PKG were found in insects and in the malaria parasite Plasmodium falciparum.

Identification of potential PKGI phosphorylation sites by analyzing the amino acid sequence of a protein is highly problematic. H-9 inhibits cGMP-dependent protein kinase with a K i value of 0.87 μM, cyclic AMP-dependent protein kinase with a K i value of 1.9 μM, and protein kinase C with a K i value of 18 μM Hidaka et al (1984). The NO/cGMP-dependent protein kinase I (G-kinase I) signal transduction pathway also plays an … Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) UniParc.

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